The Mechanism of Poly-Galloyl-Glucoses Preventing Influenza A Virus Entry into Host Cells
Identifieur interne : 000656 ( Main/Exploration ); précédent : 000655; suivant : 000657The Mechanism of Poly-Galloyl-Glucoses Preventing Influenza A Virus Entry into Host Cells
Auteurs : Hu Ge [République populaire de Chine] ; Ge Liu [Japon] ; Yang-Fei Xiang [République populaire de Chine] ; Yu Wang [République populaire de Chine] ; Chao-Wan Guo [Japon] ; Nan-Hao Chen [République populaire de Chine] ; Ying-Jun Zhang [République populaire de Chine] ; Yi-Fei Wang [République populaire de Chine] ; Kaio Kitazato [Japon] ; Jun Xu [République populaire de Chine]Source :
- PLoS ONE [ 1932-6203 ] ; 2014.
Abstract
Hemagglutinin (HA) is essential for Influenza A virus infection, but its diversity of subtypes presents an obstacle to developing broad-spectrum HA inhibitors. In this study, we investigated the molecular mechanisms by which poly-galloyl glucose (pGG) analogs inhibit influenza hemagglutinin (HA)
Url:
DOI: 10.1371/journal.pone.0094392
PubMed: 24718639
PubMed Central: 3981784
Affiliations:
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China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Kunming Institute of Botany, the Chinese Academy of Sciences, Kunming</wicri:regionArea><wicri:noRegion>Kunming</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Yi Fei" sort="Wang, Yi Fei" uniqKey="Wang Y" first="Yi-Fei" last="Wang">Yi-Fei Wang</name><affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>Division of Biomedicine Research and Development Center, Guangdong Provincial Key Laboratory of Bioengineering Medicine, National Engineering Research Center of Genetic Medicine, Jinan University, Guangzhou, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Division of Biomedicine Research and Development Center, Guangdong Provincial Key Laboratory of Bioengineering Medicine, National Engineering Research Center of Genetic Medicine, Jinan University, Guangzhou</wicri:regionArea><placeName><settlement 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populaire de Chine</country><wicri:regionArea>School of Pharmaceutical Sciences & Institute of Human Virology, Sun Yat-Sen University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Liu, Ge" sort="Liu, Ge" uniqKey="Liu G" first="Ge" last="Liu">Ge Liu</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Division of Molecular Pharmacology of Infectious agents, Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Molecular Pharmacology of Infectious agents, Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki</wicri:regionArea><wicri:noRegion>Nagasaki</wicri:noRegion></affiliation></author><author><name sortKey="Xiang, Yang Fei" sort="Xiang, Yang Fei" uniqKey="Xiang Y" first="Yang-Fei" last="Xiang">Yang-Fei Xiang</name><affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>Division of Biomedicine Research and Development Center, Guangdong Provincial Key Laboratory of Bioengineering Medicine, National Engineering Research Center of Genetic Medicine, Jinan University, Guangzhou, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Division of Biomedicine Research and Development Center, Guangdong Provincial Key Laboratory of Bioengineering Medicine, National Engineering Research Center of Genetic Medicine, Jinan University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff4"><addr-line>College of Pharmacy, Jinan University, Guangzhou, China</addr-line></nlm:aff><country 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last="Guo">Chao-Wan Guo</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Division of Molecular Pharmacology of Infectious agents, Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Molecular Pharmacology of Infectious agents, Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki</wicri:regionArea><wicri:noRegion>Nagasaki</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Nan Hao" sort="Chen, Nan Hao" uniqKey="Chen N" first="Nan-Hao" last="Chen">Nan-Hao Chen</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>School of Pharmaceutical Sciences & Institute of Human Virology, Sun Yat-Sen University, Guangzhou, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>School of Pharmaceutical Sciences & Institute of Human Virology, Sun Yat-Sen University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Zhang, Ying Jun" sort="Zhang, Ying Jun" uniqKey="Zhang Y" first="Ying-Jun" last="Zhang">Ying-Jun Zhang</name><affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>Kunming Institute of Botany, the Chinese Academy of Sciences, Kunming, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Kunming Institute of Botany, the Chinese Academy of Sciences, Kunming</wicri:regionArea><wicri:noRegion>Kunming</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Yi Fei" sort="Wang, Yi Fei" uniqKey="Wang Y" first="Yi-Fei" last="Wang">Yi-Fei Wang</name><affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>Division of Biomedicine Research and Development Center, Guangdong Provincial Key Laboratory of Bioengineering Medicine, National Engineering Research Center of Genetic Medicine, Jinan University, Guangzhou, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Division of Biomedicine Research and Development Center, Guangdong Provincial Key Laboratory of Bioengineering Medicine, National Engineering Research Center of Genetic Medicine, Jinan University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Kitazato, Kaio" sort="Kitazato, Kaio" uniqKey="Kitazato K" first="Kaio" last="Kitazato">Kaio Kitazato</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Division of Molecular Pharmacology of Infectious agents, Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Molecular Pharmacology of Infectious agents, Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki</wicri:regionArea><wicri:noRegion>Nagasaki</wicri:noRegion></affiliation></author><author><name sortKey="Xu, Jun" sort="Xu, Jun" uniqKey="Xu J" first="Jun" last="Xu">Jun Xu</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>School of Pharmaceutical Sciences & Institute of Human Virology, Sun Yat-Sen University, Guangzhou, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>School of Pharmaceutical Sciences & Institute of Human Virology, Sun Yat-Sen University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Hemagglutinin (HA) is essential for Influenza A virus infection, but its diversity of subtypes presents an obstacle to developing broad-spectrum HA inhibitors. In this study, we investigated the molecular mechanisms by which poly-galloyl glucose (pGG) analogs inhibit influenza hemagglutinin (HA) <italic>in vitro</italic> and <italic>in silico</italic>. We found that (1) star-shaped pGG analogs exhibit HA-inhibition activity by interacting with the conserved structural elements of the receptor binding domain (RBD); (2) HA inhibition depends on the number of galloyl substituents in a pGG analog; the best number is four; and when PGG binds with two HA trimers at their conserved receptor binding domains (loop 130, loop 220, and 190-α-helix), PGG acts as a molecular glue by aggregating viral particles so as to prevent viral entry into host cells (this was revealed via an <italic>in silico</italic> simulation on the binding of penta-galloyl-glucose (PGG) with HA). pGGs are also effective on a broad-spectrum influenza A subtypes (including H1, H3, H5, H7); this suggests that pGG analogs can be applied to most influenza A subtypes as a prophylactic against influenza viral infections.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Xiong, 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sortKey="Chen, Nan Hao" sort="Chen, Nan Hao" uniqKey="Chen N" first="Nan-Hao" last="Chen">Nan-Hao Chen</name><name sortKey="Wang, Yi Fei" sort="Wang, Yi Fei" uniqKey="Wang Y" first="Yi-Fei" last="Wang">Yi-Fei Wang</name><name sortKey="Wang, Yu" sort="Wang, Yu" uniqKey="Wang Y" first="Yu" last="Wang">Yu Wang</name><name sortKey="Xiang, Yang Fei" sort="Xiang, Yang Fei" uniqKey="Xiang Y" first="Yang-Fei" last="Xiang">Yang-Fei Xiang</name><name sortKey="Xiang, Yang Fei" sort="Xiang, Yang Fei" uniqKey="Xiang Y" first="Yang-Fei" last="Xiang">Yang-Fei Xiang</name><name sortKey="Xu, Jun" sort="Xu, Jun" uniqKey="Xu J" first="Jun" last="Xu">Jun Xu</name><name sortKey="Zhang, Ying Jun" sort="Zhang, Ying Jun" uniqKey="Zhang Y" first="Ying-Jun" last="Zhang">Ying-Jun Zhang</name></country><country name="Japon"><noRegion><name sortKey="Liu, Ge" sort="Liu, Ge" uniqKey="Liu G" first="Ge" last="Liu">Ge Liu</name></noRegion><name sortKey="Guo, Chao Wan" sort="Guo, Chao Wan" uniqKey="Guo C" first="Chao-Wan" last="Guo">Chao-Wan Guo</name><name sortKey="Kitazato, Kaio" sort="Kitazato, Kaio" uniqKey="Kitazato K" first="Kaio" last="Kitazato">Kaio Kitazato</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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